Clinical Challenges

The promise of personalized healthcare  - matching the right therapy to the right patient – rests with high-value diagnostics that can guide “which patients” will respond to “which therapy” within a specific disease.  Recent clinical successes in the area, however, have been generally limited to diseases that have specific mutations in a single gene.

It is now widely accepted that most chronic diseases, including asthma, diabetes, Parkinson’s disease, late-onset Alzheimer’s disease and most cancers, are far too complex to rely on genomic variations alone. Instead, the molecular drivers of disease are in fact manifested across thousands of interrelated, biochemical pathways and these disease-drivers need to be thoroughly interrogated in order to provide effective treatment options.